In NFL Week 18, the top two AFC West rivals are slated to go head-to-head for a showdown to close out the 2022-2023 season.

The Buffalo Bills (and the entire NFL community) are still coming to grips with the loss of safety Damar Hamlin, whereas the Patriots are coming fresh out of a clutch victory over the Dolphins.

Below, we will cover all you need to know to place bets on this regular season game and introduce you to NFL online sportsbooks that offer the best Patriots vs Bills odds.

Patriots vs Bills Betting Odds & Spread

New England Patriots +6.5 Spread: (+107)
Buffalo Bills -6.5 Spread: (-127)
New England Patriots to Win: (+260)
Buffalo Bills to Win: (-310)
Over/Under 42.5: (-110)

>> Sign up at BetOnline to get the best odds for this matchup

Vegas oddsmakers are very confident that the Buffalo Bills will bounce back from a heartbreaking week 17 and get back on track to finish the season. They currently hold highly favorable -310 moneyline odds compared to the +260 odds for the New England Patriots.

Let’s go ahead and break down all the main details of this NFL Week 18 matchup.

Important: The Patriots vs Bills betting odds are subject to change at online sportsbooks and may slightly differ at the time you are reading this article.

Buffalo Bills vs New England Patriots Game Info

Who: The Buffalo Bills (12-3) vs the New England Patriots (8-8)
When: Sunday, January 8th @ 1 PM EST
Location: Bills Stadium, New York
Where to Watch: CBS, online streaming
Odds: Check here

Before we break down all there is to know about this NFL Week 18 game and also some of the best picks to consider placing, let’s start with some basic information.

Here’s how to place your bet on the upcoming matchup between the New England Patriots and the Buffalo Bills.

How to Bet on the New England Patriots vs Buffalo Bills (NFL Week 18)

Step 1: Create an account

Head over to BetOnline
Click “Join” to start the account creation
Fill out all required information
Accept terms of service
Log in for the first time

Step 2: Verify your email

Head to your email inbox
Open up an email from BetOnline
Click the enclosed link back to BetOnline to finish the confirmation

Step 3: Place your Patriots vs Bills bet

Go to the Cashier page
Select your deposit method
Use the code BOL1000 to receive BetOnline’s 50% up to $1,000 bonus
Complete your deposit
Place your bets!

Why Should I Use BetOnline to Bet on the New England Patriots vs Buffalo Bills NFL Week 18 Game?

If you are looking for a solid sportsbook to bet on the upcoming matchup between the Buffalo Bills and the New England Patriots, here are some reasons we recommend heading over to BetOnline first.

Solid Betting Interface: From the main sportsbook to the live betting interface, everything is seamless to select your pick of the many betting props and options for any NFL matchup at BetOnline. You access more betting props and options than a traditional local sportsbook.

Great Odds for All NFL Games: Suppose you want to bet on more than just this matchup between the New England Patriots and the Buffalo Bills. If so, you will be right at home at BetOnline — where all NFL matchups are available for bets at great odds.

Welcome Bonus: Finally, another reason you should sign up at BetOnline over other sportsbooks is that you can claim a 50% bonus on your first deposit. If you deposit the total amount, you can get up to $1000 in bonuses.

Can I Claim a Bonus to Bet On the Patriots vs Bills?

Yes! If you want to get a bonus you can use to place bets on any NFL Week 18 matchup – not just the New England Patriots vs Buffalo Bills – then you should head straight to BetOnline. Using the bonus code BOL1000, you can get a 50% bonus on your first deposit of up to $1000.

Other great football betting sites to check out for NFL Week 18 bets:

Patriots vs Bills Predictions & Betting Lines

Need some help understanding which bets to place for the Patriots vs Bills matchup? If so, here are all the popular bets explained — alongside which picks we recommend for this matchup.

Moneyline:

When placing a moneyline bet, you simply predict the winner. The odds will help you understand what your potential winnings are. To earn $260 on a successful bet for the New England Patriots, you will need to bet at least $100 due to the +260 odds.

Similarly, to win $100 for a bet on the Buffalo Bills, you will need to put down $310 due to the -310 odds in their favor. We think that the Buffalo Bills have this game in the bag and that the moneyline bet in their favor is the smartest bet for this matchup.

However, if you want to place an early speculative bet that the Bills will cruise into the playoffs by resting star players, a +260 moonshot bet for the Patriots could be worthwhile.

>> Bet on either team to win the game outright

Over/Under:

If you want to place a bet geared towards how many points will be scored, the over/under betting line might be the best option to consider. Essentially how this bet works is that oddsmakers first decide what number will be the target -0 in this case, it is 42.5 points.

Whether you bet that the Bills and Patriots will rack up more than 42.5 points or less, there are -110 odds for these bets. The Bills currently average 28 points per game, whereas the Patriots currently average 21.3 points a game. However, we think that betting the under is the safest bet for this matchup.

The last time these two teams met, only 34 total points were scored. Both teams have elite defenses, which could quickly result in this being a low-scoring game.

>> Take the under 42.5 points at BetOnline

Point Spread:

When you want to bet on the point spread, you are betting on the margin of victory rather than the total number of points.

Currently, the Bills are projected to win this game by 6.5 points. However, if we follow trends, it would seem that it is likely that the Buffalo Bills can secure a victory by more than this amount.

The last game at Gillette Stadium between these two teams on December 1st finished 24-10 in favor of the Bills. Given that the Bills are set to play with home-field advantage. However, they have already clinched a playoff berth, making it possible for Bills Quarterback Josh Allen to rest in this matchup.

If this happens, we recommend placing a bet in favor of the 6.5-point spread with -110 odds.

Other Betting Options:

In addition to typical bets like the ones mentioned above, BetOnline and other top online sportsbooks will let you bet on individual stats like who will score the first touchdown, how the first drive of the game will finish, and more.

Remember that you can also bet on games while they are taking place. Simply log into your BetOnline account and select the “Live Betting” tab on Sunday.

>> Check out 100+ props betting markets for this game

History Games Between the Buffalo Bills & New England Patriots

Despite the Tom Brady hangover, the New England Patriots have a 77-48-1 record against the Buffalo Bills. Since 2003, the Buffalo Bills have been 8-31 against the Patriots!

However, the tide had turned in favor of the Bills after future HOF QB Tom Brady left the New England Patriots. Since then, the Bills have won four of the last five matchups against the Patriots and claimed the top spot in the AFC East for three straight years.

We expect this trend to continue heading into this final regular-season game between the New England Patriots and the Buffalo Bills. With the New England Patriots fighting for playoff presence, we expect the Bills to break out all their weapons and finish the season with a bang.

>> Check out the latest betting odds for NFL Week 18

Why Should I Bet on the New England Patriots vs Bills Game Online?

If you think that heading over to the local sportsbook is the best way to bet on this matchup between the New England Patriots and Buffalo Bills, here are a few reasons why we think betting at an online sportsbook is better.

Save Time: Time is a great asset in life. Betting online doesn’t require you to leave the house and wait in line before you place a bet.

Extra Money: Have you ever been given a bonus when walking into a sportsbook as a new player? Neither have we. However, if you head over to BetOnline for the first time, you can get a 50% bonus on your first deposit up to a total value of $1000.

Live Betting: In addition to having unique player props and betting options, you can also place bets on the New England Patriots vs Buffalo Bills game while the game is taking place.

Previously in NFL Week 17:

Best Buffalo Bills vs New England Patriots Predictions: NFL Week 18

The playoff seed status of the Buffalo Bills heading into this matchup is still questionable until we get news about the suspended matchup between the Bills and Bengals that took place on Monday. On the other hand, the New England Patriots need to win or hope for a miracle to make the playoffs.

Tragic Return to the Field

The biggest story heading into this matchup is the horrifying collapse of Bills safety Damar Hamlin that took place in the suspended week 17 matchup against the Bengals. In the aftermath, both sides of the field and the NFL all recognized that player safety is more important than a football game — suspending the game indefinitely.

Heading into week 18, tears will likely be shed on both sides of the field. We expect Josh Allen and the electrifying Bills offense to put their heart out on the field for Hamlin. However, it is imaginable that the Bills decide to take the week to grieve and rest starters going into the playoffs. It all depends on how the playoff seed for the Bills gets impacted.

The New England Patriots, on the other hand, can control their destiny and march into the wild card round if they win this game. If they lose the game, they will need the Jets and Browns to win and a win or tie from the Jaguars.

How the Buffalo Bills Can Win

The Buffalo Bills need to show up in tip-top shape to set themselves to win against the New England Patriots. They currently have one of the most explosive offenses in the league, averaging 381.4 yards per game while only giving up 317.7 yards per game (#5) and a measly 16.5 (#2) points per game on defense.

The Bills Mafia had the Patriots’ number in their last matchup – beating them comfortably 24-10. The Bills dominated the Patriots on the defensive end. Josh Allen put up an impressive 22/33 for 223 yards alongside two touchdowns in this game. Star WR Stefon Diggs had seven grabs for 92 yards and a touchdown in this game.

We expect this week’s matchup to play out similarly.

>> Bet on Buffalo Bills to win

How the New England Patriots Can Win

The Patriots will need to pull out all of their tricks and memorable plays if they want to fool this Bill’s defense, which held them to just 242 total yards in their last matchup. They need to let their hearts on the field and get their offense going if they hope to beat the Bills and secure a spot in the wild card round.

That said, the New England Patriots have also proven themselves on the defensive side of the field. They are currently ranked #5 in points allowed per game – with just 19.5. If they really hold their end on the defensive side of the field while converting more third downs on offense, it is feasible that they can win this matchup.

In the last game between these two teams, the Patriots converted a horrendous 3 of 12 third downs. They punted the ball six times and had a whopping 62 yards in penalties. If they perform like this, they mark themselves off again this week against the Bills.

>> Bet on New England Patriots to win

Pending Information Will Impact Which Bets Are Smartest

Until we have conclusive results on the health of Damar Hamlin and, subsequently, what will come to be of the suspended week 17 matchup against the Cincinnati Bengals, it will be difficult to gain clarity on how the Bills will handle themselves in this week 18 matchup.

If they had won the game and the Chiefs lost their Saturday matchup against the Raiders, they would have clinched the #1 seed and could have rested QB Josh Allen and other start players. However, we highly recommend waiting for all this information to clear before betting confidently.

Guide to Betting on the New England Patriots vs Buffalo Bills Game

Who is Favored to Win — the Patriots or the Bills?

The Buffalo Bills are favored to win this matchup with -310 odds. They are projected to win by 6.5 points. On the other hand, the Bills have +260 odds of winning this game.

What Just Happened at the Bills Bengals Game?

The entire NFL community was shocked on Monday night when Bills safety Damar Hamlin collapsed due to a cardiac arrest in the first quarter of the matchup against the Bengals. The NFL subsequently suspended the game until further notice.

What is the Patriots’ Record Against the Bills?

The Patriots currently lead the all-time series against the Bills 77-48-1.

Can the Patriots Make Playoffs with a Loss to the Bills?

The Patriots can make the playoffs if they lose against the Bills. If they lose the game, they will need the Jets and Browns to win their games. In addition, they will need a win or tie from the Jaguars.

Can the Bills Clinch the 1 Seed?

Until the news of Damar Hamlin and the week 17 matchup between the Buffalo Bills and Cincinnati Bengals comes out, it is unclear whether or not the Buffalo Bills can still get the #1 seed in the AFC.

How Do I Choose the Best NFL Betting Site for the Patriots vs Bills Game?

The first thing you should do is consider the quality of the betting site and interface. Look for plenty of betting options, competitive odds, and a seamless user experience. Then, consider what banking methods are supported, their reputation, and the customer service.

That said, we’ll be placing our bets at BetOnline.

Related Betting Guides:

Ready to Place Your New England Patriots vs Buffalo Bills Bets?

If you want to bet on this NFL Week 18 matchup between the New England Patriots and the Buffalo Bills, the smartest bet to place right now is a moneyline bet in favor of the Bills.

We also recommend you consider placing an under bet and a bet against the 6.5 spread at BetOnline.

In professional sports, even the worst teams can beat the best teams. However, keep in mind that NFL games are notoriously unpredictable. Therefore, please use your own discretion and do your own research before deciding what bets to place for this matchup.

Thanks for reading, and please remember to bet responsibly!

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