The upcoming matchup between the Arizona Cardinals and the San Francisco 49ers is stated to be an allegedly easy win for the 49ers.
But does this mean you should put all your money on the moneyline right now?
Perhaps not, as there are plenty of other value bets to place – some of which we’ll discuss right here in this article.
Let’s go ahead and take a look at the best Cardinals vs 49ers odds.
Cardinals vs 49ers Betting Odds & Spread
- Arizona Cardinals +14 Spread: (-110)
- San Francisco 49ers -14 Spread: (-110)
- Arizona Cardinals to Win: (+675)
- San Francisco 49ers to Win: (-1050)
- Over/Under 40.5: (-110)
Important: The Cardinals vs 49ers odds displayed on this page are subject to change and may be slightly different at the time you’re placing your bets.
With very high -1050 odds in favor of the Arizona Cardinals, there isn’t any doubt in Vegas’ mind that the Cardinals will seal away the 2022-2023 regular season with a victory.
In fact, these odds are so high that many people might avoid placing moneyline bets – unless they have faith in the Arizona Cardinals.
On the other hand, the Arizona Cardinals are coming into this matchup feeling disrespected after getting destroyed 38-10 in Mexico City during week 11. Given their home-field advantage, it is possible that this game could be played to a different tune.
However, with the 49ers facing a possible #1 seed with a victory, we expect them to come with all weapons ready. Let’s go ahead and jump into the important game details.
Arizona Cardinals vs San Francisco 49ers Game Info
- Who: The Arizona Cardinals (4-12) vs. the San Francisco 49ers (12-4)
- When: Sunday, January 8th @ 4:25 EST
- Where: Levi’s Stadium, California
- How to Watch: NBC Sports Bay Area, NFL+, Foxsports.com
- Odds: Check here
Before diving deep into this week 18 National Football League matchup, it’s essential to start with the basics – where can you get the best possible betting odds?
Below, we will cover all you need to know to get started at BetOnline and activate a nice 50% deposit bonus of up to $1000 as a new player.
How to Bet on Arizona Cardinals vs. San Francisco 49ers (NFL Week 18)
Step 1: Create an account
- Follow this link to head over to BetOnline
- Select “Join” to get started with your account
- Fill out all required information
- Accept the terms of service
- Click “Create Account”
Step 2: Verify your email
- Go to your email inbox
- Open up the email from BetOnline
- Click the link enclosed to verify your account
Step 3: Place your Cardinals vs 49ers bet
- Open the Cashier page
- Select your deposit method
- Use the code BOL1000 to get a bonus of up to $1000
- Start placing bets in the sportsbook!
Why Should I Use BetOnline to Bet on the Arizona Cardinals vs San Francisco 49ers NFL Week 18 Game?
If you are still new to using online sportsbooks, you might not have heard about BetOnline yet. Here are some top reasons you should head here first for this matchup — and all other National Football League games.
Professional Quality: BetOnline is constantly ranked as one of the best football betting sites. This is due to the top-quality user interface, some of the best odds around, and coverage of all NFL matchups, along with any other popular professional sport.
Welcome Bonus: If you want to get started with some fresh powder in addition to the money you are ready to put down, BetOnline will give you a nice bonus. New players can use the bonus code “BOL1000” to get a 50% deposit bonus of up to $1000 in value.
Many Betting Options: We all have heard about moneyline, over/under, and spread bets, but what about live betting, player props, and game props? With many additional betting options for any matchup, you can always place a wise bet that can convert into some nice winnings.
Can I Claim a Bonus to Bet On the Arizona Cardinals vs San Francisco 49ers Game?
Yes, use the bonus code “BOL1000” at the cashier to get a 50% bonus tacked onto your initial deposit – up to $1000 in bonus cash. The minimum deposit to qualify for this promotion is $55, and the wagering requirements are pretty fair at 10x.
Check out some other great football betting sites offering bonuses that you can use to bet on NFL Week 18 games:
Cardinals vs 49ers Predictions & Betting Lines
With basic information out of the way, let’s get into essential details. Below, we will explain the common bets to place for the upcoming regular season finale between the Arizona Cardinals and the San Francisco 49ers.
If you want to place a moneyline bet, the only factor you have in mind is who will win the game. If you see negative odds (such as the -1050 odds for the 49ers), this is how much money you need to stake to win $100. Similarly, positive odds (like the +675 odds for the Cardinals) demonstrate how much money you will win if you bet $100.
If you are going to place a moneyline bet in favor of the Cardinals, you either have inside information nobody else has, or you are comfortable throwing your money away.
We see no reason to place any other moneyline bet than one in favor of the 49ers.
When you consider placing an over or under bet, you are confident about how many points will be scored on both sides of the field. Currently, there are 40.5 projected points in this matchup. The last time these two teams met, there were 48 points scored.
In the case of this game, the most significant variable will be how the 49ers play on both sides of the field. The 49ers arguably have the best defense in the NFL. The Arizona Cardinals are not mainly known for a good offense – but they allow the 2nd fewest points on the defensive end.
In this game, we expect both teams to play well defensively. We think that the safest bet is an under bet.
When you bet on the point spread, you are betting on the margin of victory. The projected margin of victory is 14 points. The odds for both sides of the spread in this matchup are -110.
The 49ers average 369.1 yards per game – the fifth-ranked offense in the NFL. They are also ranked 7th in points per game – with an impressive 25.8 points per game on average. Their offense ranks top-tier in most categories. Unless the Cardinals put forth their best effort, we think that betting the -14 spread in favor of the 49ers here is the best option.
Other Betting Options:
If you miss out on betting before the game starts, don’t worry — live betting is also available at BetOnline.
In addition, you can place other bets, like who will get to 10 points first (-371 odds for the 49ers), whether the team to score first wins (-278 odds for yes), and who will get the most first downs (-385 odds for the 49ers).
We recommend that you consider any of these bets!
History Games Between the Arizona Cardinals & San Francisco 49ers
This NFC West rivalry stretches back to 2002 when the league realigned the divisions. The two franchises have games dating back to 1951 when the Cardinals were known as the Chicago Cardinals. As of today, the 49ers lead the all-time series 33-29.
Since 2002, the 49ers have won 5 NFC West titles compared to the two won by the Arizona Cardinals. The last time these two teams met up, the 49ers gave them a 38-10 clocking in Mexico City.
Both teams have not done well in the playoffs in recent years. The 49ers haven’t won a Super Bowl since 1995. The Arizona Cardinals had hopes of a Super Bowl in 2008 but ended up losing. They have never won a Super Bowl in franchise history.
Why Should I Bet on NFL Week 18 Online?
If you are still unsure whether you want to bet on the Cardinals vs 49ers online, you might be a bit old school and prone to betting at your local sportsbook. Here are the top reasons you should use online sportsbooks like BetOnline when placing bets on NFL games.
Convenience: This is likely the most obvious – you save time when you place bets online, as you’re not required to actually visit a sportsbook and wait in line to place a bet. Simply create an account, deposit, and bet right away.
Bonus Money: You have probably never been given a bonus simply for going into the sportsbook. However, new users at BetOnline can get 50% added onto their first deposit – up to a total value of $1000.
More Betting Options: Finally, betting with a site like BetOnline gives you much more potential than the typical money line, over/under, and spread bets at your local sportsbook. For any NFL matchup, you can bet on over 100 player props, game props, and live betting options.
Best Arizona Cardinals vs San Francisco 49ers Predictions: NFL Week 18
With the essential details out of the way, let’s dive into the previous game of this matchup between the Arizona Cardinals and the San Francisco 49ers.
To Say That the Cardinals vs 49ers is One-Sided is an Understatement
The Arizona Cardinals have no shot at getting into the playoffs. They also don’t need anything other than draft pick positioning – currently projected to be the #4 pick in the 2023 NFL Draft. The only stats in which they are top 5 include the number of plays, pass attempts, completed passes, and points allowed.
It would be a stretch to say that they have any shot at winning this game. After all, they are after a top-tier 49ers team that is good on both sides of the field. They allow the second least amount of points a game while being the third most likely team in the NFL futures market to take home the Super Bowl (+500 odds at writing).
How the San Francisco 49ers Can Win
The San Francisco 49ers are expected to bring all their starters with them over to Levi’s Stadium. After all, they must win on Sunday if they have any hopes of heading into the playoffs with the #1 seed in the NFC. To win this game, they must continue playing as they have been all season.
We expect the 49er’s defense to show up. However, it will be interesting to see how budding QB Brock Purdy will perform. If the 49ers struggle and only put up 10 points, as they did in their loss to the abysmal Denver Broncos, the Cardinals could rally to an upset. If they succeed on offense, we expect the elite 49ers’ defense to take care of the rest.
How the Arizona Cardinals Can Win
Let’s be clear: you shouldn’t bet on the Arizona Cardinals to win unless you are okay with throwing away money. The +675 money line odds for the Arizona Cardinals make them the biggest underdog in week 18.
The Arizona Cardinals’ defense needs to play like never before this season if they hope to get past the 49ers. Stars like J.J. Watt (who just announced his retirement) need to lay their heart and souls on the field to give room for the struggling offense – who will be starting QB David Blough with an 0-6 record as a starter.
All Eyes Are on the Defenses In This NFL Week 18 Clash
The Cardinals’ offense has been beaten and bruised to a pulp this year, losing various players like Kyler Murray, Colt McCoy, Deandre Hopkins, and more. The defense must hold the 49ers’ offense to minimal points to ignite some life into this team. This way, the below-average Arizona Cardinals offense has plenty of elbow room.
Similarly, the 49ers come into this game with the best rush defense, the third-least points allowed, and the third-fewest TDs allowed. If they continue this success in week 18, expect the Cardinals to score 10 points or fewer – much as they did in Mexico City.
Previously in NFL Week 17:
- Bears vs Lions betting odds
- Bengals vs Bills
- Steelers vs Ravens betting lines
- Packers vs Vikings odds
- Chiefs vs Broncos betting odds
- Saints vs Eagles predictions
How Many Times Have the Arizona Cardinals Beaten the 49ers?
The Arizona Cardinals have matched up 62 times against the 49ers. Throughout the all-time series, the Cardinals are 29-33-0 against the 49ers.
Who Will Win This NFL Week 18 Game – 49ers or Arizona Cardinals?
Do the 49ers Have a Chance at the Playoffs?
The 49ers have clinched a playoff berth for this season. If they win this matchup against the 49ers, and the Giants beat the Eagles on Sunday, they will also get the #1 NFC playoff seed.
Which is the Most Likely Team to Win the Super Bowl
The Kansas City Chiefs are the most likely team to win the Super Bowl (+375). The Buffalo Bills (+400) also have a good shot at taking home the Super Bowl. Finally, the San Francisco 49ers are the third most likely team to win it all (+500).
What is the Best NFL Sportsbook to Bet On Arizona Cardinals vs 49ers?
If you want to bet on this matchup between the 49ers and the Arizona Cardinals, we recommend you head to BetOnline. They have a top-tier user interface, the best odds, and a 50% bonus of up to $1000 for new players.
How Do I Choose the Best NFL Betting Site for Arizona Cardinals vs 49ers?
If you want to bet at the best NFL betting site, there are some things you should keep in mind. For starters, the betting odds are the bottom line. Then, consider factors such as the user experience, the number of betting options, and if there is a bonus for new players.
We’ll be placing our Cardinals vs 49ers bets at BetOnline – if that helps you make a decision.
More in NFL Week 18:
Ready to Place Your Arizona Cardinals vs. 49ers Bets?
If you want to get the best odds on the Arizona Cardinals vs 49ers game, head straight over to BetOnline and use the bonus code “BOL1000” to get a 50% bonus up to $1000 as a new bettor.
However, please remember that NFL games are notoriously unpredictable. Although our bets were carefully considered and planned, it doesn’t mean that they are guaranteed.
Thanks for reading, and please remember to bet responsibly!
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